A very evil crook named Addictim tried to sell his dangerous drug product called Crystal Twyst to the streets of Empire City. He even tried to joined up with Big Boss and his crooks to help promote the drug product. But Big Boss rejected his offer. For once, there is a spark of morality inside this otherwise corrupted, fat man. He even order his crooks to reject Addictim's product completely. Easier said than done. For unfortunately, Berserko accidentally injected himself with Addictem's Crystal Twyst and is seen dying from the deadly drug overdose, Big Boss had no choice but to beg the C.O.P.S. team to help save his nephew, which they did. As a result, Big Boss and his Crooks....of all things...joined forces with C.O.P.S. in a successful effort to take down Addictem and end his drug selling business for good.